Article Abstract

Association of periodontal disease indices with risk of gastric adenocarcinoma

Authors: Nikolaos A. Chrysanthakopoulos, Stergios A. Reppas, Aggelos A. Oikonomou


Background: Epidemiological investigations have linked periodontal pathogens to several systemic diseases, including cardiovascular disease, diabetes mellitus, respiratory disease, and systemic infections, associations possibly mediated through markers of systemic infection and inflammation. It has also been suggested a possible association between periodontal disease (PD) and cancer risk in different organs, based on the link between chronic inflammation and cancer pathogenesis.
Methods: The study population was consisted of 724 individuals (426 males and 298 females). A total of 248 participants were suffered from non-cardia gastric cancer (GC). The participants were interviewed and undergone an oral clinical examination. Statistical analysis of data was performed by using chi-square test and multivariate logistic regression models.
Results: Smoking (OR =2.99, 95% CI: 0.80–5.64), previous H. pylori infection (OR =4.55, 95% CI: 1.60–8.78) and genetic predisposition (OR =5.27, 95% CI: 1.15–8.40) were found to be significantly associated with GC risk. Clinical attachment loss (CAL) (OR =2.26, 95% CI: 0.84–4.06) was also found to be significantly associated with the mentioned risk after adjusting for confounders.
Conclusions: CAL as an index for PD severity, smoking, previous H. pylori infection and genetic predisposition were statistically associated with the risk of GC development.