The mechanisms of INK4-ARF inactivation
Inactivation of the INK4-ARF locus is one of the most frequent events in cancers. The mechanistic basis of epigenetic silencing was not well understood. Recently Gamell et al. found a novel mechanism, in which loss of an E3 ubiquitin ligase E6AP results in the silencing of INK4-ARF locus through E2F-CDC6 pathway.