New exciting possibilities for the development of precision medicine therapies to restore the expression of the INK4/ARF locus

Loss of expression of the genes encoded in the INK4/ARF locus (p14^ARF, p15^INK4B and p16^INK4A) is a common event in human cancers (1). Recent publications shed light on the mechanisms involved in the INK4/ARF locus silencing, which opens an exciting window for the design of new therapeutic strategies for cancer patients.