Novel insight on the impact of choline-deficiency in sepsis

Ahmed Al-Humadi, Hussam Al-Humadi, Charis Liapi


Choline, an essential dietary component, is a selective α7 nicotinic acetylcholine (ACh) receptor agonist. It plays an important role in various metabolic and non-metabolic pathways including inflammatory pathways. Systemic inflammatory response syndrome activated by bacterial endotoxins is a critical clinical condition associated with high rates of morbidity and mortality and related multiple organ dysfunction; immunological imbalance is associated with deteriorated outcome of septic patients. Choline-deficiency can be seen in different physiological and pathological states, and can be linked to the pathway of a septic condition. Assessment of the nutritional status has a significant impact on improving treatment output, healing process and prognosis of septic patients. The aim of this review is to explore the significant impact or the protective and supportive role of choline on selective pathological and/or inflammatory pathways in experimental or clinical models of sepsis.